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KMID : 0360319940260030369
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 3 p.369 ~ p.376
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Treatment of Advanced Gastric Cancer with Oral UFT and Leucovorin
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정성균
김기찬/김열홍/신상원/김준석
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Abstract
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We conducted a phase Ⅱtrial of oral administration of UFT and leucovorin in patients with advanced gastric adenocarcinoma.
Sixteen patients entered on this study from September 1992 to November 1993. The treatment regiman consisted of oral administration of UFT (480mg/㎡/day), and leucovorin (25mg/㎡/day) for 21 consecutive days. The dosage of UFT was adjusted after
each
treatment and the treatment was repeated every 4 weeks.
The total number of administered treatments in 16 patients was 55 and the median number was 4.
Among 14 evaluable patients, 1 patient (7.2%) had a complete response and 3 patients (30%) achieved paritial response resulting in an overall response rate of 28.5%. The median duration of response was 15 weeks (4+- 48+). The median survival time
for
all 16 patients was 24 weeks (4+-48+).
Gastrointestinal toxicity was common and toxicity over grade 3 included diarrhea in 7 patients (43.8%), mucositis in 2 patients(12.5%) and anorexia, nausea and vomiting in 1 patient respectively. Grade 1 leukopenia was observed in 3
patients(18.8%).
In conclusion, oral administration of UFT and leucovorin in patients with advanced gastric cancer who have poor general condition seems to be comparable to ther chemotherapy regimens in efficacy and toxicity.
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KEYWORD
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